Main Conference - Day 2 (5월 21일)
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Streams
6:30am - 7:30am60 mins
TIDES Fun Run and Registration
Breakfast Spotlight Presentations
7:45am - 8:15am30 mins
Breakfast Spotlight Presentations 1
Providing a Wide Variety of High-purity gRNAs for Cutting-edge CRISPR Gene Editing Technology
- Takuya Miyagawa - Research Associate, Sumitomo Chemical Co., Ltd.
7:45am - 8:15am30 mins
Breakfast Spotlight Presentations 2
Green Chemistry Approaches in the Manufacturing of Peptide-Oligonucleotide Conjugates
- Chris Gothard, PhD - Director of Technical Marketing and Communications, CPC Scientific
7:45am - 8:15am30 mins
Breakfast Spotlight Presentations 3
WuxiTIDES Spotlight Presentation
Concurrent Tracks
8:25am - 8:30am5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Chairman’s Remarks: Advances in Oligonucleotide Medicinal Chemistry & Preclinical
- Troels Koch, PhD - Chief Technology Officer, MiNa Therapeutics
8:25am - 8:30am5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Emerging Approaches to Enzymatic Synthesis for DNA and RNA: Challenges and Prospects
- Yogesh Sanghvi, PhD - President, Rasayan Inc.
8:25am - 8:30am5 mins
Peptide Discovery to CMC
Chairman’s Remarks: Targeted Peptide Radiopharmaceuticals
- Daniel DeOliveira, PhD - Vice President, Drug Substance Development and Manufacturing, Kailera Therapeutics
8:25am - 8:30am5 mins
mRNA Technology and Applications
Chairman’s Remarks: mRNA Manufacturing and CMC Strategies
- Andreas Kuhn, PhD - Senior Vice President RNA Biochemistry & CMC Development, BioNTech SE
8:25am - 8:30am5 mins
Delivery of Macromolecules
Chairman’s Remarks: Genome Editing Delivery
- Luis Brito, PhD - Vice President, Delivery Platform, Beam Therapeutics
8:30am - 9:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
The Impact of Phosphoryl Guanidine (PN) Backbone Linkages on AIMer-mediated RNA Editing Across Cell and Tissue Types
- Chandra Vargeese, PhD - Chief Technology Officer, Wave Life Science
8:30am - 9:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Emerging Approaches to Enzymatic Synthesis of Nucleic Acids
- Marcel Hollenstein, PhD - Head of Research Unit, Institut Pasteur
8:30am - 9:00am30 mins
Peptide Discovery to CMC
Progress in the Development of Targeted Peptide Radiopharmaceuticals: Challenges, Successes and Case Studies
- Jens Kaufmann, PhD - Director Technical Operations, 3B Pharmaceuticals
8:30am - 9:00am30 mins
mRNA Technology and Applications
Biofoundry-in-a-Box™: By-Design mRNA Manufacturing in a Box
- Harris Makatsoris - Academics Professor of Sustainable Manufacturing Systems, King's College London
8:30am - 9:00am30 mins
Delivery of Macromolecules
Delivery Strategies for Genome Editing
- Melissa Bonner, PhD - Chief Scientific Officer, nChroma Bio
9:00am - 9:30am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
From Seed to Solution: Ionis’ Answer to siRNA Off-Target Effects
- Mehran Nikan, PhD - Research Fellow, Ionis Pharmaceuticals
9:00am - 9:30am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Meeting the Manufacturing Needs of Nucleic Acids Used in Modern Medicines: Novel and Efficient Enzymatic Processes for mRNA and Oligonucleotide Synthesis
- Helge Zieler, PhD - CEO, Primrose Bio
9:00am - 9:30am30 mins
Peptide Discovery to CMC
New Strategies for Prolonging Tumor Retention of Radioconjugates - An Example from FAP-directing RLT
- Andreas Goutopoulos, PhD - CEO and Co-founder, Actithera
9:00am - 9:30am30 mins
mRNA Technology and Applications
Addressing Manufacturing Challenges: Intensified, Continuous and Digitalised Production of High-quality mRNA Medicines at Low Cost
- Mabrouka Maamra - Project Manager, University of Sheffield
9:00am - 9:30am30 mins
Delivery of Macromolecules
Innovations in Delivery Technologies to Advance Base Editing to the Clinic
- Manmohan Singh, PhD - Chief Technology Officer, Beam Therapeutics
9:30am - 10:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Next-generation Sequence-specific DNA-targeted Inhibitors
- Raman Bahal, PhD - Associate Professor, Department of Pharmaceutical, University of Connecticut
9:30am - 10:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Oligonucleotide CMC for Sustainable and Scalable Enzymatic siRNA Manufacturing
- Alison Moore - Chief Technical Officer, Codexis
9:30am - 10:00am30 mins
Peptide Discovery to CMC
68Ga/225Ac-FL-031, A New Generation of Theranostic Pair for the Treatment of SSTR2-positive Cancers
- Fa Liu, PhD - Chief Scientific Officer, Full-Life Technologies
9:30am - 10:00am30 mins
mRNA Technology and Applications
mRNA Manufacturing: Mastering Impurity Detection and Removal for Enhanced Performance
- Jonathan Abysalh - Sr. Director, US Section Head Process Development, Sanofi
9:30am - 10:00am30 mins
Delivery of Macromolecules
Optimization and Characterization of mRNA/LNPs for Targeted Delivery in vivo
- Steven Wolk, PhD - President, Siniwali Biotechnology Solutions
Networking Refreshment Break in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
10:00am - 10:45am45 mins
Networking Refreshment Break in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Networking Refreshment Break in Poster and Exhibit Hall
10:10am - 10:20am10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Comparative Analysis of Diastereomeric Distribution in siRNA Synthesis: Phosphoramidite Chemistry vs. Enzymatic Synthesis
- Stephanie Forget, PhD - Senior Scientist, Protein Engineering, Codexis
10:20am - 10:30am10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Multidimensional RNA Profiling for Therapeutic Development Success
- Wayne Doyle - Head of Platform, Eclipse Bioinnovations
10:30am - 10:40am10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Selectivity Enabling NanoShell, SENS(TM): Advancing Gene Therapy Development through Innovative Tissue-selective Delivery
- Saudat Fadeyi, PhD, MBA - Head of Business Development and Strategy, Samyang Biopharm USA
10:45am - 11:15am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
The Impact of Nucleoside Analogs on the Activity of Oligonucleotides that Direct ADARs for Therapeutic RNA Editing
- Peter Beal, PhD - Professor, Department of Chemistry, UC Davis
10:45am - 11:15am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Solving the Scale Problem: Template-independent Enzymatic Synthesis of siRNA Oligonucleotides
- Daniel Ahlstedt - Chief Operating Officer and Co-Founder, EnPlusOne Bio
10:45am - 11:15am30 mins
Peptide Discovery to CMC
Bicycle® Radionuclide Conjugates for Radioisotope Delivery to Solid Tumors
- Anusha Regupathy - Senior Scientist, Medicinal Chemistry, Bicycle Therapeutics
10:45am - 11:15am30 mins
mRNA Technology and Applications
Evolving Lipid Nanoparticles to Optimize Clinical Application of messenger RNA Therapeutics
- Ying Tam, PhD - Chief Scientific Officer, Acuitas Therapeutics
10:45am - 11:15am30 mins
Delivery of Macromolecules
Innovating Nucleic Acid Delivery: RAPTOR, Artificial Intelligence, and the Future of CAR-M
- Melissa Deck - Director of Platform, Liberate Bio
11:15am - 11:45am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Recent Updates on Guanidine Bridged Nucleic Acid (GuNA) and 5′-cyclopropylene DNA (5′-CP), Demonstrating Their Potential to Improve Tolerability and Potency of Therapeutic Oligonucleotides
- Ajaya Shrestha, PhD - Chemistry Group Lead, Luxna Biotech
11:15am - 11:45am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
DNA and RNA Libraries Produced though Massively Parallel, Light-directed Microarray Synthesis
- Jory Lietard - Associate Professor, University of Vienna
11:15am - 11:45am30 mins
Peptide Discovery to CMC
From Discovery to First-in-Human Application of a Targeted Radiotherapeutic against Fibroblast Activation Protein Alpha (FAPa)
- Peter Timmerman, PhD - Head of Peptide Science, Biosynth
11:15am - 11:45am30 mins
mRNA Technology and Applications
Adapting LNP Platform Manufacturing Methods to Enable Clinical Applications of Next Generation mRNA-LNP Therapeutics
- Ed Yaworski - Chief Technology Officer, Genevant Sciences Corp
11:15am - 11:45am30 mins
Delivery of Macromolecules
Inhaled and In Vivo SORT LNP Delivery of RNA and Gene Editing Therapies
- Marco Weinberg, PhD - Senior Vice President, Head of Research, ReCode Therapeutics
11:45am - 12:15pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Late Breaking Presentation
11:45am - 12:15pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chemical Synthesis of Long Oligos
- Shiyue Fang, PhD - Professor, Michigan Technological University
11:45am - 12:15pm30 mins
Peptide Discovery to CMC
Radio-labelled-peptide for Disease Treatment
- Ali Azhdarinia, PhD - Associate Professor, IMM-Center for Translational Cancer Research, UT Health Houston
11:45am - 12:15pm30 mins
mRNA Technology and Applications
A Single-Dose Thermostable LNP Platform for Prophylactic mRNA Vaccines
- Roland Bottger, PhD - Senior Research Scientist, CureVac SE
11:45am - 12:15pm30 mins
Delivery of Macromolecules
Late Breaking Presentation
12:15pm - 12:20pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Peptide Discovery to CMC
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
mRNA Technology and Applications
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Delivery of Macromolecules
Transition to Spotlight Presentation Rooms
Spotlight Presentations
12:20pm - 12:50pm30 mins
Spotlight Presentation 1
A Novel Ultrafiltration/Diafiltration Method to Achieve High Concentrations of Nucleic Acids
- Sven Warhaut, PhD - Vice Head of Manufacturing, BioSpring GmbH
12:20pm - 12:50pm30 mins
Spotlight Presentation 2
Tag-Assisted Peptide Synthesis (TAPS) - Development of an Efficient, Sustainable and Cost-Effective Continuous Liquid-Phase Process
- Mimoun Ayoub, PhD - Senior VP, Global Head of Peptide and Oligonucleotide Platforms, CordenPharma International
12:20pm - 12:50pm30 mins
Spotlight Presentation 3
St Pharm Spotlight Presentation
12:20pm - 12:50pm30 mins
Spotlight Presentation 4
Pioneering Enzymatic siRNA Manufacturing at Large Scale: A Cost-Effective Hybrid Approach with Solution Phase Synthesis
- Daisuke Takahashi, PhD - Executive Specialist, Ajinomoto Co. Inc.
12:20pm - 12:50pm30 mins
Spotlight Presentation 5
Achieving Control in Oligo Manufacturing: Innovations, Strategies, and Technologies
- Cory Hinz - Engineering Manager, Asahi Kasei Bioprocess
- Thomas Rupp - Managing Director, Axolabs Berlin GmbH
12:50pm - 1:55pm65 mins
Networking Luncheon in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Networking Luncheon in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
1:10pm - 1:20pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Scalable Drying of Thermosensitive TIDES in Solvents Using Electrostatic Drying (ESD)
- Katherine Buzecky - Director of Scientific Services, Fluid Air
1:20pm - 1:30pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Quality Control Strategy of Delivery Ligand of Galnac
- Rocky Liu - International Business Director, Wuhu Huaren
1:30pm - 1:40pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Mepsgen TIDES Talk
1:40pm - 1:50pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Nutcracker Therapeutics TIDES Talk
Concurrent Tracks
1:55pm - 2:00pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Co-Chairs' Remarks: From Novel RNA Technologies to Therapeutics
- Seth Alexander, PhD - Director of RNA Technologies, Prime Medicine
- Elissa Hobert, PhD - Director of Discovery Technologies, NewCo
1:55pm - 2:00pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Oligonucleotide CMC Strategies and Case Studies
- Kathryn Ackley, PhD - CMC Consultant Specializing in Oligonucleotides, Independent Consultant
1:55pm - 2:00pm5 mins
Peptide Discovery to CMC
Chairman’s Remarks: CIPPS Session: Unleashing the Power of Peptides for Therapeutics and Agriculture
- David Craik, PhD - Professor of Biomolecular Structure, University of Queensland
1:55pm - 2:00pm5 mins
mRNA Technology and Applications
Chairman’s Remarks: mRNA Preclinical and Clinical Data
- Frank DeRosa, PhD - Chief Technology Officer & Global Head of Research, mRNA Center of Excellence, Sanofi
1:55pm - 2:00pm5 mins
Delivery of Macromolecules
Chairman’s Remarks: Novel Drug Delivery
- Stephen Spagnol, PhD - Director, Enabling Technologies, Merck
2:00pm - 2:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Novel Design of Self-amplifying RNA and Formulation Challenges of Large RNA Payloads
- Suiyang Liao, PhD - Postdoctoral Research Fellow, University of British Columbia
2:00pm - 2:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Merging New Technologies to Advance the Synthesis of Oligonucleotides
- Scott May, PhD - VP Chemistry - Genetic Medicine, Eli Lilly and Company
2:00pm - 2:30pm30 mins
Peptide Discovery to CMC
Peptide-lipid Interplay: Unravelling How Bioactive Peptides Permeate Cell Membranes
- Sonia Henriques - Associate Professor in Biochemistry, The University of Queensland
2:00pm - 2:30pm30 mins
mRNA Technology and Applications
In Vivo Engineering of Cells using Targeted Lipid Nanoparticles
- Priya Karmali, PhD - Chief Technology Officer, Capstan Therapeutics
2:00pm - 2:30pm30 mins
Delivery of Macromolecules
Rational Design of Lipid Nanoparticles for Extrahepatic Nucleic Acid Delivery
- Jayesh Kulkarni - Co-Founder & Chief Scientific Officer, NanoVation Therapeutics
2:30pm - 3:00pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Generating Tomorrow's Medicines Today through the Language of Life
- Ewen Cameron, PhD - VP, Head of RNA and Discovery Technologies, Sail Biomedicines
2:30pm - 3:00pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
New Purification Techniques for Oligonucleotides
- Joe Guiles, PhD - Head of Chemical Development, Nucleic Acids Solution Division, Agilent Technologies
2:30pm - 3:00pm30 mins
Peptide Discovery to CMC
A Platform for the Intracellular Generation and High-throughput Screening of Cyclic Peptide Libraries
- Ali Tavassoli, Ph.D. - CSO, Curve Therapeutics, University of Southampton
2:30pm - 3:00pm30 mins
mRNA Technology and Applications
Delivery of RNA Gene Writers in vivo using Lipid Nanoparticles for Correction of Sickle Cell Mutation in HSCs and generation of CAR-T Cells.
- Rebecca Goldman, PhD - Associate Director, Formulations, Tessera Therapeutics
2:30pm - 3:00pm30 mins
Delivery of Macromolecules
Delivery of RNA Therapeutics: The Great Endosomal Escape!
- Steven Dowdy - Professor, UCSD School of Medicine, USA
3:00pm - 3:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
tRNA at the Frontier: Developing Medicines to Treat Stop Codon Disease
- Caroline Kohrer, PhD - Senior Vice President, Discovery Platform, Alltrna
3:00pm - 3:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Purification Scale up: A Case Study of Volume-Based Scale-Up Approaches in Oligonucleotide Chromatography
- Stephen Dietrich - Associate Director, RNA Process Development, Sarepta Therapeutics
3:00pm - 3:30pm30 mins
Peptide Discovery to CMC
Cell Penetrating Properties of Cyclotides and Their Applications for Intracellular Targets
- David Craik, PhD - Professor of Biomolecular Structure, University of Queensland
3:00pm - 3:30pm30 mins
mRNA Technology and Applications
Translation of an Optimized Self-replicating RNA Platform with an Expanded Clinical Therapeutic Index
- Andrew Geall, PhD - Co-founder and Chief Development Officer, Replicate Bioscience
3:00pm - 3:30pm30 mins
Delivery of Macromolecules
A Versatile LNP Platform for in vivo Delivery of mRNA to Cells
- Chun Yang, PhD - Senior Director of Biology, Nitto BioPharma
Networking Refreshment Break in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
3:30pm - 4:15pm45 mins
Networking Refreshment Break in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Networking Refreshment Break in Poster and Exhibit Hall
3:40pm - 3:50pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
Overcoming Impurities in Therapeutic APIs: Transforming Reagent Solutions for Solid and Liquid Phase TIDES Synthesis
- Colin Smith - Innovation Leader, Pharma, Aurorium
3:50pm - 4:00pm10 mins
TIDES Talks in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
A Strategy to Develop Potential and Safe mRNA-based Therapeutics
- Akiko Yanagiya, PhD - Team Leader, Arcalis
4:15pm - 4:45pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
sa-mRNA's Structure and Manufacturing Process Affect Its Final Structure and Functionality
- Anna Senczuk - Senior Director, mRNA Process Development, CSL Seqirus
4:15pm - 4:45pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Nitto Avecia Presentation Topic TBA
4:15pm - 4:45pm30 mins
Peptide Discovery to CMC
Engineering Approaches for Improving Stability and Potency of Peptide-based Drug Leads
- Nicole Lawrence, PhD - Senior Research Fellow, Institute for Molecular Bioscience and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland
4:15pm - 4:45pm30 mins
mRNA Technology and Applications
BioNTech’s Individualized Neoantigen Specific Immunotherapies Against Cancer: Concept and Clinical Update
- Andreas Kuhn, PhD - Senior Vice President RNA Biochemistry & CMC Development, BioNTech SE
4:15pm - 4:45pm30 mins
Delivery of Macromolecules
Mirai Bio's ML-driven Delivery Platform Provides Fully Integrated, End-to-end Genetic Medicine Development Capabilities for the Biotech Industry
- Jagesh Shah, PhD - Senior Vice President, Head of Platform, Mirai Bio
4:45pm - 5:15pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
RNA Technologies That Drive CRISPR-Cas9 Editing
- Nadia Cumbal - Principal Scientist, Intellia Therapeutics
4:45pm - 5:15pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Process Development and Scale-up for Peptide-conjugated Oligonucleotides
- Dana Chreng - Director, Manufacturing & Operations, Ionis
4:45pm - 5:15pm30 mins
Peptide Discovery to CMC
“Better-for-You”, Bioactive Peptides for Food
- Michelle Colgrave, PhD - Professor of Food & Agricultural Proteomics, Edith Cowan University
4:45pm - 5:15pm30 mins
mRNA Technology and Applications
mRNA Program for Rare Diseases
- Joseph Kupferman, PhD - Senior Director, Clinical Development, Moderna
4:45pm - 5:15pm30 mins
Delivery of Macromolecules
In vivo Reversible Programming of T cells with SAIL’s Targeted NPs Encapsulating eRNA-encoded CAR for the Treatment of Autoimmune Diseases and Beyond
- Michael Mingueneau, PhD - Head of Immunology, Sail Biomedicines
5:15pm - 5:45pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
In Vivo CRISPR Editing of Genetic Regulatory Regions Results in Functional Upregulation of Target Protein and Reduction of Disease-Associated Biomarker
- Paul Wrighton, PhD - Senior Scientist II, In Vivo Gene Editing, Editas Medicine
5:15pm - 5:45pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Regulatory Guideline Development for Oligonucleotides
- René Thürmer, PhD - Deputy Head, BfArM Federal Institute for Drugs & Medical Devices
5:15pm - 5:45pm30 mins
Peptide Discovery to CMC
The Infinite Loop: ML for Discovery, Delivery, and Rapid Manufacturing of Potential Medicines
- Bradley Pentelute, PhD - Professor, Chemistry, Massachusetts Institute of Technology
5:15pm - 5:45pm30 mins
mRNA Technology and Applications
Late Breaking Presentation
5:15pm - 5:45pm30 mins
Delivery of Macromolecules
RNA Delivery Based on a New Class of Synthetic Cationic Materials
- Robert Waymouth, PhD - Robert Eckles Swain Professor of Chemistry, Stanford University
5:45pm - 6:45pm60 mins
Networking Reception in Poster and Exhibit Halls (Grand Ballroom and Harbor Ballroom)
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