소그룹에 의한 원활한 디스커션으로, 인터랙티브 참가에 의해 포커스 토픽에 관한 문제 해결 및 향후 협업으로 연결됩니다.

버즈란?

PepTalk의 버즈 세션은 업스트림 공정의 단백질 발현과 생산부터 다운스트림 공정의 스케일 업과 제조까지 중요하고 흥미로운 토픽에 대해 참가자가 자극적인 디스커션을 펼칩니다. 공통의 관심을 가진 다양한 분야의 과학자 사이에서 브레인스토밍과 인터랙티브 문제 해결을 시행하는 모더레이터 진행형 디스커션입니다.
The discussions are scheduled for:

Wednesday, January 21, 7:30 - 8:15 am

BuzZ Sessions with Continental Breakfast

Recombinant Protein Production - Part 1

BuzZ Table 1: Recent Developments in Tools for Protein Production: What's Hot and What Have We Not Got (but Need)
Moderator: Christopher Cooper, DPhil, Founder, Protein Sciences, Enzymogen Consulting

• Alternative proteases for fusion tag removal
• Cost-effective reagent-based QC methods
• Protein-labeling technologies
• Up-and-coming fusion tags and promising expression systems
• Is there one hypothetical reagent that would be transformational to your protein production efforts?

BuzZ Table 2:  Revisiting Construct Design, Cloning Strategies, and Expression Systems
Moderator: Rob Meijers, PhD, Head, Biological Discovery, Institute for Protein Innovation

• What is the use of codon optimization? Revisiting gene synthesis
• HTP cloning methods; Golden gate assembly, Gibson cloning, etc
• Expression systems revisited (Old and up and coming)
• Expression chaperones, fusion proteins
• Open source cell lines, vectors and media

Automation in Protein Discovery

BuzZ Table 3: Expanding the bsAb Toolbox through Automated Workflows
Moderator: Alexandra Cabatingan, Resin Sales Specialist, Cytiva

• How MabSelect Mild Elution enables streamlined and reproducible platforms
• Using MagSepharose for high-throughput screening
• Automated downstream applications using AKTA chromatography systems and their impact on workflow efficiency

Advanced Tools for Purification and Quality

BuzZ Table 4: Increasing Purification and Characterization Efficiency
Moderator: Gwenny Go, Senior Scientist, Infectious Disease and Vaccines, Merck

• Recent advanced tools and technologies driving purification workflow improvements
• Ensuring the quality of purified proteins: applying diverse analytics and orthogonal measures
• Exploring automated and semi-automated characterization processes. For example, do you trust traditional Western or capillary electrophoresis? Does automated characterization actually save time?

Analytical Strategies for Novel Biologics

BuzZ Table 5: Trends in Analytical Data
Moderator: Marcel Passon, PhD Researcher, Biopharmaceutical Technology, Technical University of Munich

• Join us for an engaging discussion on emerging trends shaping the future of analytical data.
• Explore how organizations are leveraging advanced analytics to enhance decision-making.
• Learn how AI-driven insights are transforming strategies and enabling smarter, data-driven outcomes.

BuzZ Table 6: Current Control Strategies for Characterization- What is Next?
Moderator: Kevin Zen, PhD, Principal Consultant, Biologics CMC Consulting

• How effective are current control strategies in managing variability and ensuring quality?
• What emerging tools and technologies are shaping the next phase of characterization control?
•  What does the future of characterization look like?

Peptide Targets: Discovery, Expression, and Validation

BuzZ Table 7: Challenges in Advancing Peptides to the Clinic
Moderator: Raymond S. Norton, PhD, Professor, Monash Institute of Pharmaceutical Sciences, Monash University

• Proteolytic stability
• Pharmacokinetics
• Oral bioavailability
• Cell surface vs intracellular targets
• Cost of goods: synthetic vs recombinant

Novel Formats and New Antibody Approaches

BuzZ Table 8: Antibody-Based Technologies for CNS Drug Delivery
Moderator: Peter M. Tessier, PhD, Albert M. Mattocks Professor, Pharmaceutical Sciences & Chemical Engineering, University of Michigan

• CD98hc vs transferrin receptor shuttling: pros/cons & applications
•  Impact of bispecific antibody properties on CNS delivery efficiency, selectivity, and retention
•  Tailoring antibody shuttles to specific CNS drug delivery applications: nucleic acids, proteins, enzymes, IgGs, and more 
•  Outstanding challenges in biologics delivery to the CNS and future directions

BuzZ Table 9: Engineering Multispecifics for the Clinic: Potency, Safety, and Manufacturability
Moderator: Hamzeh Rahimi, PhD, Scientist, City of Hope National Medical Center

• Safety-by-design mechanisms
• Potency vs. selectivity engineering
• Manufacturability & developability funnel: what are some early predicters of a go/no go?