Cambridge Healthtech Institute's 16th Annual

Immunology for Biotherapeutics
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Understanding and Manipulating the Immune System for Therapeutic Advantage

2024³â 10¿ù 15ÀÏ - ALL TIMES EDT

Many of the exciting advances in drug discovery and development today concern the immune response and its manipulation and control. Our understanding of immune involvement in therapeutic disorders and their treatment is developing rapidly. T and B lymphocyte subsets, innate lymphoid cells (ILCs), macrophages, dendritic cells, and cytokines are all involved in a complex manner. There is the potential for manipulation for therapeutic advantage, yet the danger of disastrous consequences if not well understood. At Cambridge Healthtech Institute¡¯s 16th Annual Immunology for Biotherapeutics symposium, attendees will find out how to utilize the immune system and overcome inhibitory factors for biotherapeutic development without overlooking potential safety issues.

2024³â 10¿ù 15ÀÏ (È­)

Registration and Morning Coffee8:30 am

CURRENT UNDERSTANDING OF IMMUNE MECHANISMS

9:50 am

Chairperson's Remarks

Kannan Natarajan, PhD, Staff Scientist, NIAID, NIH

10:00 am FEATURED PRESENTATION:

Antigen Processing and Presentation: The Basis of T Cell Activation

Kannan Natarajan, PhD, Staff Scientist, NIAID, NIH

Antigen-presenting cells process protein antigens into peptides for binding by either Major Histocompatibility Class I (MHC-I) or Class II (MHC-II) molecules, which are then displayed at the cell surface as peptide/MHC complexes, where they are recognized by T cell receptors leading to T cell activation. Cell biological, biochemical, and structural details of these processes as we now understand them will be discussed.

10:30 am

Role of IgE and IgG/IgG4 in Modulating Type I Hypersensitivity Reactions in Human Allergic Disease

Robert Hamilton, PhD, D.ABMLI, Professor, Medicine & Pathology, Clinical Immunology & Allergy, Johns Hopkins University

This presentation will overview the four areas of hypersensitivity: immediate Type I IgE-mediated, Type II antibody-dependent cytotoxicity, Type III immune-complex-mediated, and delayed-Type hypersensitivity. Type I human allergic disease will then be examined, covering its pathophysiology, current diagnostic strategies, four modes of disease management, and special caveats relating to food, drug, venom, and respiratory allergic disease. Finally, the new discipline of molecular allergology will be highlighted with an emphasis on ten cross-reactive allergen families and how allergenic molecules have improved the accuracy of allergy diagnosis.

Networking Coffee Break11:00 am

11:15 am

The Role of the Innate Immune System and Implications for Biotherapeutics

Han-Yu Shih, PhD, Investigator, NeuroImmune Regulome, National Institutes of Health National Eye Institute

The field of innate lymphoid cell (ILC) biology has progressed rapidly, highlighting these cells¡¯ roles in immunity, barrier tissue integrity, and homeostasis. ILCs can be classified based on cytokine production, mirroring patterns in CD4 T helper (Th) cell analogs. Unlike Th cells, ILCs respond promptly to pathogens without needing antigen-specific receptor recognition. Understanding ILC differentiation and immunoregulation is key to developing new treatments for autoimmunity, infection, and cancer.

11:45 am

Complement as an Apex Regulator of Tissue Inflammation

Ben Afzali, MD, PhD, FRCP, Earl Stadtman Investigator, Immunoregulation Section, Kidney Diseases Branch, NIDDK, NIH

Our lab investigates tissue inflammation, injury, and repair, focusing on gene expression influenced by micro-environmental signals and transcription factors using functional genomics approaches. An important aspect of our work centers around complement components produced by cells in tissues. In this talk, we will discuss the mechanisms and roles of locally produced complement in inflammation, how this influences tissue biology, and the key transcriptional regulators involved.

Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own12:15 pm

Session Break12:45 pm

HARNESSING THE IMMUNE SYSTEM FOR BIOTHERAPEUTICS

2:00 pm

Chairperson's Remarks

Paul Moore, PhD, CSO, Zymeworks

2:05 pm

Pushing the Boundaries of Antibody-Based Therapeutics through Multispecifics and Drug Conjugates

Paul Moore, PhD, CSO, Zymeworks

Antibody-based therapeutics have provided great therapeutic benefit to many patients across various disease states. Multispecific antibodies afford therapeutic opportunities not feasible with single-target antibodies or combinations, while drug conjugates provide opportunity to extend therapeutic benefit through combining the targeting specificity of an antibody with a "payload." Examples of these advances will be summarized in the context of molecule design, target selection, biological characterization, and clinical benefit.

2:35 pm

Harnessing the Body¡¯s Natural Immune Response to Fight Cancer

Daron Forman, PhD, Senior Principal Scientist, Discovery Biotherapeutics, Bristol Myers Squibb Co.

Immunotherapy has shown remarkable response rates in some previously hard-to-treat cancers by redirecting the body¡¯s own immune system to recognize and eliminate tumor cells. Here, we will discuss the current state of immunotherapy by briefly covering cytokine therapy, cancer vaccines, adoptive immunotherapy, and immunomodulation therapy.

Networking Refreshment Break3:05 pm

3:30 pm

Emerging Immunogenicity Obstacles for Next-Generation Biotherapeutics

Andreas Hollenstein, PhD, Principal Scientist, Immunosafety, Roche

Since the beginning of immunotherapy using monoclonal antibodies, we have pushed the limits for higher efficiency of this therapeutic modality. This shift did not come without trade-offs for safety and immunogenicity. In this presentation, I will talk about several examples of drug-enhancing approaches that also can have a profound impact on immunogenicity. Understanding the underlying mechanisms could help us to stay away as far as possible from this immunogenic transformation and lead to the development of better drugs for patients.

4:00 pm PANEL DISCUSSION:

Harnessing the Immune System for Biotherapeutics

PANEL MODERATOR:

Paul Moore, PhD, CSO, Zymeworks

PANELISTS:

Daron Forman, PhD, Senior Principal Scientist, Discovery Biotherapeutics, Bristol Myers Squibb Co.

Andreas Hollenstein, PhD, Principal Scientist, Immunosafety, Roche

Close of Immunology for Biotherapeutics Symposium4:30 pm

Dinner Short Course Registration5:00 pm

Recommended Dinner Short Course*5:30 pm

SC4: Recent Advances with Cell and Gene Therapy
*Separate registration required. See short course page for details.

2024³â 10¿ù 17ÀÏ (¸ñ)

Recommended Dinner Short Course*6:00 pm

SC5: Advice on Putting Together an Integrated Summary of Immunogenicity
*Separate registration required. See short course page for details.

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