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Charles Keller, Scientific Director, Children¡¯s Cancer Therapy Development Institute

Hervé Tiriac, Researcher, University of California-San Diego

Michael Graner, Professor, University of Colorado Anschutz Medical Campus

Roger Royse, Partner, Haynes & Boone, LLP -- Conference Chairperson
Solid Tumors 2025: Technologies, Diagnostics & Therapeutics
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Progress in Research Trends Targeting Various Classes of Solid Tumors
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Childhood Cancers
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Charles Keller, Scientific Director, Children¡¯s Cancer Therapy Development Institute
Charles Keller Biographical
Sketch
Charles¡¯ research focuses on the development of more effective, less toxic therapies for childhood cancers. His special interest is advanced disease that has spread beyond the initial location of the cancer or which makes the tumor unresectable. Charles
has co-chaired the brain tumor developmental therapeutics committee (CNS-DVL) of the Children¡¯s Oncology Group and is a member of the soft tissue sarcoma (STS) committee of Children¡¯s Oncology Group. He has also regularly been a standing
or ad hoc member of NIH/NCI Study Sections.
Charles attended Tulane University where he received a degree in Biomedical Engineering prior to attending Baylor College of Medicine where he received his M.D. degree. After completing his internship and residency in Pediatrics
at Texas Children¡¯s Hospital, Charles trained in Pediatric Hematology-Oncology at the University of Utah and with 2007 Nobel laureate, Mario Capecchi. Charles has authored over 150 scientific publications and is a recognized expert in the
biology of childhood sarcomas and the preclinical investigation of childhood cancers. Charles is also a co-founder of Artisan Biopharma (a company helping translate drug discoveries to clinical use) and Tio Companies that improves drug safety
and cancer drug effectiveness*.
* overlap between cc-TDI, Artisan Biopharma, Teo Therapeutics and Tio Companies is overseen by a conflict of interest management committee.
Hervé Tiriac, Researcher, University of California-San Diego
Hervé Tiriac Biographical
Sketch
Dr. Tiriac received his Ph.D. from UC San Diego studying pre-mRNA splicing and transcription with Dr. Tracy Johnson. Herve¡¯s research focuses on developing systems for precision medicine that may be utilized in the fight against pancreatic cancer. Herve did his postdoctoral fellowship with David Tuveson at Cold Spring Harbor Laboratory where he collaborated with Hans Clevers to establish protocols for PDAC organoid generation and testing.
Michael Graner, Professor, University of Colorado Anschutz Medical Campus
Michael Graner Biographical
Sketch
Michael Graner received his PhD in Biochemistry from the University of Illinois followed by post-doctoral and research faculty work at the University of Arizona, shifting gears from the Drosophila extracellular matrix to cancer immunotherapy. He then took at faculty position at Duke University¡¯s Tisch Brain Tumor Center, followed by his current position as Professor in Neurosurgery at the University of Colorado Denver (Anschutz Medical Campus). He is also a member of the University of Colorado Cancer Center, the Colorado Clinical and Translational Sciences Institute, the MAVRC Program, and holds a Visiting Professorship Appointment at the Shenzhen Third People¡¯s Hospital (China) and an adjunct faculty appointment at Colorado State University. Graner has a long-standing interest in cell stress responses, which led to cancer vaccine development (including one in clinical trials), which somehow led to the world of extracellular vesicles (EVs). His lab currently concentrates on signaling mechanisms involving EVs, in particular the transfer of stressed phenotypes from stressed tumor cells to unstressed ones via EVs.
Roger Royse, Partner, Haynes & Boone, LLP
Roger Royse Biographical
Sketch
Roger Royse is a startup lawyer in Silicon Valley and a pancreatic cancer patient. Roger was diagnosed with stage 2B pancreatic adenocarcinoma in July 2022 after taking a multi cancer early detection blood test. After 6 months of chemotherapy and surgery and an experimental cancer vaccine, Roger currently has no evidence of disease.
Roger has been active for many years with the Leukemia Lymphoma Society having been its Bay area Man of the Year in 2012. Since his diagnosis, Roger has become the Silicon valley Advocacy Chair for the Pancreatic Cancer Action Network (PanCan) and has joined the board of the Cancer Patient Lab.org, a nonprofit dedicated to evidence based therapies. Roger also hosts www.cancerstartup.com, a platform for cancer therapy technology startups to demo their solutions. Roger has since testified to an FDA Advisory committee on multi cancer early detection and has been featured in many publications including the Wall Street Journal on MCED.
Roger believes in the patient being proactive and taking personal responsibility for their health and being very involved in their treatment decisions based on evidence based treatments.
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20 November 2025
08:00
Conference Registration: Garnet Gallery
Conference Registration, Materials Pick-Up, Coffee and Continental Breakfast
20 November 2025
09:00
Garnet Gallery, VOCO Hotel


Roger Royse, Partner, Haynes & Boone, LLP -- Conference Chairperson
Patient Driven Oncology
A summary of the patient¡¯s perspective on cancer care.
20 November 2025
09:29
Garnet Gallery, VOCO Hotel
Session Title: Research Strides in Understanding of Various Cancer Classes -- Presentations on Mechanisms of Oncogenic Development, Molecular Switches, and Signal Transduction
20 November 2025
09:30
Garnet Gallery, VOCO Hotel

Charles Keller, Scientific Director, Children¡¯s Cancer Therapy Development Institute, United States of America
Inhibition of Oncogenic Fusion Proteins in Pediatric Solid Tumors
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and often also occurs in adolescents and young adults. Clinically, survival amongst metastatic RMS patients has remained dismal and unimproved for decades. Metastatic RMS harboring PAX3/7::FOXO1 is generally not survivable. RMS has two major forms: the alveolar subtype (ARMS or Fusion+ RMS) is characterized in 66% of cases by a t(2;13) translocation creating an oncogenic PAX3::FOXO1 chimeric transcription factor. Approaches that have brought repurposed targeted therapeutics to clinical trials, approaches to create bespoke inhibitors and degraders, and technologies that enable pharma to quickly and economically empower pharma to develop de novo therapeutics for rare solid tumors will be presented.
20 November 2025
10:00
Garnet Gallery, VOCO Hotel

Michael Graner, Professor, University of Colorado Anschutz Medical Campus, United States of America
Title to be Confirmed
20 November 2025
10:30
Garnet Gallery, VOCO Hotel
Mid-Morning Coffee Break and Networking
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Solid Tumors 2025: Technologies, Diagnostics & Therapeutics Conference °³ÃÖÁö
SelectBIO is pleased to host this Solid Tumors 2025: Technologies, Diagnostics & Therapeutics Conference at VOCO Laguna Hills: An IHG Hotel -- Laguna Hills, California.
VOCO Laguna Hills
25205 La Paz Road
Laguna Hills, California 92653, USA
This hotel in Southern California is easily accessible from Los Angeles and San Diego via Interstate-5 (I-5).
- The nearest airport is: John Wayne Airport (SNA) - 13.7 miles from the hotel.
- From Los Angeles International Airport (LAX) - the hotel is 52.9 miles.
- The hotel is within a short drive of Disneyland and Legoland California, as well as Laguna Beach, Newport Beach, as well as shopping and dining at South Coast Plaza in Costa Mesa.
- All conference sessions, exhibition as well as networking reception will be held in the Conference Center at VOCO Laguna Hills.
To make your Hotel Reservations Online: Click the Button Below to Open the Hotel Booking Website This will provide a SelectBIO discounted rate for booking hotel rooms.




For any hotel reservation-related issues, or if you need any help with hotel bookings, please contact us.
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