Cambridge Healthtech’s 3rd Annual

Emerging Technologies at the Point-of-Care
(POC(Point-of-Care)의 최신 기술)

첨단 기술 활용에 의한 POC(Point-of-Care)에서 환자의 결과 개선

2019년 8월 21일~22일

 

Point-of-care testing (POCT) allows clinicians to make rapid decisions to improve clinical outcomes, cost and patient satisfaction. Join us at Emerging Technologies at the Point-of-Care as we discuss the newest technologies in the fastest growing sectors of diagnostics to improve clinical care and their path to clinical use.

Final Agenda

8월 21일(수)

10:30 am Registration


11:30 Plenary Keynote Session

11:30 Chairperson’s Remarks

Charles Mathews, Principal, ClearView Healthcare Partners

 

 

 

 

 

11:40 Plenary Keynote Presentation: FDA Updates: Now and Looking to the Future

Tim Stenzel, MD, PhD, Director, Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, U.S. Food and Drug Administration

Introduction and background of the new Office Director of OIR and updates on precision medicine and other initiatives at the FDA.

12:10-1:05 pm Plenary Keynote Discussion: Proposals and Solutions for Diagnostic Reform Including Oversight of Laboratory Developed Tests (LDTs)

Moderator:
Cynthia A. Bens, Senior Vice President, Public Policy, Personalized Medicine Coalition


  • How are stakeholders influencing congressional activity on the Verifying Accurate Leading-edge IVCT Development (VALID) Act?
  • How will the VALID Act change the current oversight landscape for diagnostics, including LDTs?
  • How are policymakers addressing the role of CMS and CLIA in the VALID Act?
  • How will increased regulatory and oversight activities at the FDA affect the diagnostics industry?
  • What impact will changes in diagnostics regulation and oversight have on patient care?

Panelists:

Julie Khani, MPA, President, American Clinical Laboratory Association (ACLA)


Donald E. Horton, Jr., Senior Vice President, Global Government Relations & Public Policy, Laboratory Corporation of America Holdings


Susan Van Meter, Executive Director, AdvaMedDx


Tara Burke, PhD, Senior Director, Public Policy & Advocacy, Association for Molecular Pathology (AMP)


Lasiter_LauraLaura Lasiter, PhD, Science Policy Analyst, Friends of Cancer Research


1:05 pm Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:35 Ice Cream & Cookie Break in the Exhibit Hall with Poster Viewing


KEYNOTE PANEL SESSION:

WHAT MAKES EMERGING TECHNOLOGY ATTRACTIVE?

2:05 Chairperson’s Opening Remarks

Deetz_DavidDavid Deetz, Co-Founder, CTO, Ativa Med


2:15 How Siemens is Enabling Precision Diagnostics

Deshpande_ManishManish Deshpande, PhD, Vice President, R&D, Point of Care BU, Siemens Healthcare


2:25 Focus on Sensor Tech for POCT

Pamidi_PrasadPrasad V. A Pamidi, PhD, Director, Sensor Development, R&D, Instrumentation Laboratory, A Werfen Company


2:35 Guiding R&D for the Next Generation Diagnostics

Matt Bates, Head of R&D, Abbott


2:45 Mastering New Product Spaces and Competitive Landscapes

Menezes_NinaNina Menezes, Head, Marketing Innovation, Abbott


2:55 Keynote Panel Discussion: What Makes Emerging Technology Attractive?

Moderator: David Deetz, Co-Founder, CTO, Ativa Med

Panelists: Manish Deshpande, PhD, Vice President, R&D, Point of Care BU, Siemens Healthcare

Prasad V. A Pamidi, PhD, Director, Sensor Development, R&D, Instrumentation Laboratory, A Werfen Company

Matt Bates, Head of R&D, Abbott Point-of-Care

Nina Menezes, Head, Marketing Innovation, Abbott Point-of-Care

  • Analysis of the latest trends in lab testing
  • Identification of hot new tests and the value they create
  • Creating new uses for established tests by adding in new tech

3:40 Sponsored Presentation (Opportunity Available)

4:10 Refreshment Break in the Exhibit Hall with Poster Viewing

커넥티비티에 의한 POC(POINT OF CARE) 진단의 진보

4:55 Chairperson’s Remarks

Matt Quinn, MBA, Senior Advisor, Health Technology, HRSA

5:00 Advancing Use of Innovative Health Technologies in the Safety Net

Matthew_QuinnMatt Quinn, MBA, Senior Advisor, Health Technology, HRSA

The Health Resources and Services Administration (HRSA), an agency of the U.S. Department of Health and Human Services, is the primary federal agency for improving healthcare to people who are geographically isolated, economically or medically vulnerable. This session will describe how HRSA advances the use of health technologies to achieve its mission of improving health and achieving health equity through access to quality services, a skilled health workforce and innovative programs.

5:30 Smart and Connected Molecular Diagnostics at the Point-of-Care

Liu_ChangchunChangchun Liu, Associate Professor, Biomedical Engineering Department, University of Connecticut, UConn Health

Smartphones have a growing and pervasive influence on our daily life. Especially, with the rapid development of microfluidics technology, the incorporation of microfluidics technology with smartphone-based detection technology will create a new paradigm shift towards affordable, smart and connected health monitoring. In this talk, I will introduce our synergistically enhanced colorimetric molecular detection method, molecular diagnostic chips, smart connected systems and their applications in early cancer screening (e.g., HPV-associated cancer) and infectious disease detection (e.g., Zika virus, HIV virus) at the point-of-care.

6:00 Q-POC – Molecular Diagnostics Point-of-Care 2.0

oHalloran_JonathanJonathan O’Halloran, CSO, QuantuMDx Group Ltd

QuantuMDx has developed a novel, low-cost sample to answer molecular diagnostics device aimed at both low and high resource settings. The device performs both qPCR and end-point PCR followed by a microarray, all within a single ultra-low-cost disposable. The company’s first assay is an HPV assay, due for launch in 2020, that individually genotypes 13 high-risk sub-types of the virus, directly from a swab sample in under 30 minutes.

6:30 Close of Day

6:30 Dinner Short Course Registration


6:45 - 9:15 pm Recommended dinner Short Course*

SC15: Microfluidics and Lab-on-a-Chip Devices for POCT: Technologies and Commercialization

Myatt_ChrisChris Myatt, Founder & CEO, MBio Diagnostics, Inc.

Additional Speakers to be Announced

This short course will provide an overview of microfluidic techniques, including valved and valve-less devices, pumped systems, and capillary flow approaches. Practical examples will keep the discussion grounded in the realization of commercializable devices. We will discuss engineering approaches to enhance the advantages and minimize the challenges. Throughout, the science will be linked to the commercial case for these devices, including a full discussion of a recent success story of a centrifugal microfluidic molecular assay system.

*Separate registration required.

8월 22일(목)

7:15 am Registration


7:30 Problem Solving Breakout Discussions with Continental Breakfast

Technologies to Enable Point-Of-Care… Anywhere?

Moderators: Dionysios Christodouleas, PhD, Assistant Professor, Department of Chemistry, University of Massachusetts Lowell

Shawn Mulvaney, PhD, Section Head, Surface Nanoscience and Sensor Technology Section, Chemistry, US Naval Research Laboratory

  • In the future, POCT will be common at the home, in the battle field, etc. How can we start planning now?
  • So your sensor works, but what about the sample prep? Does that strategy work at home? In a field?
  • Do you have the "Tricorder"? How sophisticated does POCT medicine get before my backpack gets too full?

Multiplex at the POC

Moderator: Mehdi Javanmard, PhD, Assistant Professor, Department of Electrical and Computer Engineering, Rutgers University

  • How to balance increasing technological complexity with the need for low cost?
  • Integrating new biomarkers, ex. miRNA, protein, etc
  • How to tackle sample prep, integration on chips/assays?
  • Translating from the bench to a cartridge

The Next Big Step Forward in Microfluidics;  Microstructured Films Combined with Polymer or Glass Parts

Moderators:  Maria Bauer, PhD, CEO, Myropartners, Salzburg, Austria

Violeta Tacheva, MSc, Project Engineer, Stratec Consumables, Cambridge MA, USA

  • What are microstructured films and foils
  • Advantages of the roll to roll process 
  • Industrial partnership with the Kurz Group
  • Applications of microstructured foils in POC and IVD applications 

새로운 POC 검사(POCT) 기술의 검증

8:25 Chairperson’s Remarks

Jonathan O’Halloran, CSO, QuantuMDx Group Ltd

8:30 Clinical Needs, Validation and Implementation Strategies for Novel Point-of-Care Technologies

Wang_PingPing Wang, PhD, DABCC, Chief, Clinical Chemistry, Director, Core Laboratory Hospital of University of Pennsylvania

The field of point-of-care technologies has witnessed strong growth, as evidenced by new clinical or consumer products, or research and development directions. Only when combined with appropriate strategies for clinical needs assessment, validation and implementation, these technologies may significantly impact care delivery and associated outcomes and costs. In this presentation, I will discuss clinical needs, validation and implementation strategies for novel point-of-care technologies from two perspectives: as a practicing clinical laboratory director, and as a technology researcher and developer.

9:00 Diagnostic Workstation: A New Approach to Diagnosing Primary-Care Patients Enables New Processes

Deetz_DavidDavid Deetz, Founder, CTO, Ativa Med

Ativa’s Diagnostic Workstation integrates a synergistic array of breakthrough diagnostic and AI technologies that has the potential to disrupt the current process of primary care because it facilitates:


  • Much faster diagnoses - It permits healthcare personnel to run the major blood/urine panels immediately themselves, which enables the provider to diagnose a patient within moments, rather than hours or days
  • Improved diagnoses – Its cloud-based AI enables protocol-driven test selection and provides meaningful interpretation to improve diagnoses
  • Expanded ability to detect serious diseases in primary care

9:30 Sponsored Presentation (Opportunity Available)

10:00 Coffee Break in the Exhibit Hall with Poster Viewing

LFI(LATERAL FLOW IMMUNOASSAYS)와 리트머스지에 의한 진단

11:00 Chairperson’s Remarks

Karl Poterack, MD, Medical Director, Applied Clinical Informatics, Mayo Clinic

11:05 Catalytic Nanoparticles as Labels in Lateral Flow Immunoassays

Mulvaney_ShawnShawn Mulvaney, PhD, Section Head, Surface Nanoscience and Sensor Technology Section, Chemistry, US Naval Research Laboratory

Lateral-flow immunoassays (LFIs of LFIAs) are widely used point-of-care technology. Visually-read, LFIAs typically use colloidal gold or colored latex as the reporter elements for the antibody-antigen binding event. Due to their visual extinction coefficients, the intensity of these labels are limited which ultimately limits the sensitivity of the assay. We have substituted specially-prepared, colloidal palladium for the traditional labels and use it as a chemical catalyst to produce an easily-observable, stable, blue dye that localizes at the capture line. Importantly, the catalyst is heat stable, functions at room temperature, under physical conditions, and results in up to a 500-fold increase in sensitivity with only five additional minutes of development.

11:35 Paper Devices for Medical Self-testing at Home: Opportunities and Challenges

Christodouleas_DionysiosDionysios Christodouleas, PhD, Assistant Professor, Department of Chemistry, University of Massachusetts Lowell

Diagnostic devices for home use should operate with minimal user involvement, be able to analyze untreated samples, and have low cost. Paper devices are inexpensive and, if they are designed carefully, could be capable of analyzing untreated samples and be fully integrated. In this presentation, I will discuss examples of paper devices that allow biochemical testing without user involvement and point toward areas of future research in paper diagnostics to address current challenges.


12:05 pm Paper-Based Surface-Enhanced Raman Scattering Lateral Flow Strips for Point-of-Care Applications

Wu_NickNianqiang (Nick) Wu, Professor, Mechanical and Aerospace Engineering, West Virginia University

This presentation will present our effort to develop plasmonic nanostructures for amplifying surface-enhanced Raman scattering (SERS) signals. It will also show how to incorporate SERS sensors into paper-based lateral flow strips (PLFS) as point-of-care tools. The PLFS is composed of the on-chip sample pretreatment, flow control and detection components. Moreover, this talk will demonstrate measurement of the traumatic brain injury (TBI) protein biomarkers in clinical samples by the SERS-based PLFS.

12:35 Sponsored Presentation (Opportunity Available)

1:05 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:35 Dessert Break in the Exhibit Hall with Poster Viewing

웨어러블 디바이스와 이미지 데이터의 처리

2:15 Chairperson’s Remarks

Wilbur A. Lam, MD, PhD, Associate Professor, Wallace H. Coulter Department of Biomedical Engineering and Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Georgia Institute of Technology and Emory University School of Medicine

2:20 Wearable Monitors in Health Care: Signal or Noise?

poterack_karlKarl Poterack, MD, Medical Director, Applied Clinical Informatics, Mayo Clinic

Widely used wearable devices like activity trackers and smart watches continuously measure physiologic data during everyday activities. Utilizing this data requires a paradigm shift for health care, since traditionally this data was only collected during patients’ healthcare visits. This presentation will cover the types of data that can be collected, the associated technical challenges, as well as the system changes required in order to be able to utilize this data to improve care and outcomes.

 

2:50 Development of a Smartphone App for Non-Invasive Detection of Anemia Using Only Patient-Sourced Photos

Lam_WilburWilbur A. Lam, MD, PhD, Associate Professor, Wallace H. Coulter Department of Biomedical Engineering and Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Georgia Institute of Technology and Emory University School of Medicine

We introduce a paradigm of non-invasive, on-demand diagnostics for hematologic diseases using only a smartphone app and photos. We initially targeted anemia, characterized by low blood hemoglobin levels, which afflicts >2 billion people. Our app estimates hemoglobin levels by analyzing color and metadata of fingernail smartphone photos and screens for anemia (hemoglobin levels <12.5 g/dL) with a 97% sensitivity (n = 100 subjects). Moreover, with personalized calibration, this system achieves an accuracy of ±0.92 g/dL compared to gold standard hemoglobin levels (n = 16 subjects), empowering chronic anemia patients to serially monitor their hemoglobin levels instantaneously and non-invasively.

웨어러블 디바이스와 이후 기술

3:20 Portable and Wearable Electro-Fluidic Micro/Nanotechnologies for Health and Environmental Monitoring

Mehdi Javanmard, PhD, Assistant Professor, Department of Electrical and Computer Engineering, Rutgers University

Portable and wearable devices for measuring physical parameters such as ECG, pulse oximetry, and temperature are widely used for health monitoring. The ability to continuosly monitor physiology at the biomolecular leveI can further provide significant information in understanding the state of health. In this talk, I will discuss my group's work on fabricating micro- and nanosensing platforms for biomolecular and biochemical detection. In the first part of my talk, I will discuss wearable platforms we are developing for detection of cells and also inflammatory proteins in blood and saliva. I will then discuss a novel scheme for barcoding microparticles nanoelectronically, for multiplexed detection of analytes. I will then discuss our development of a novel electrochemical sensor using reduced graphene oxide for detection of inflammatory markers in exhaled breath condenstate for management of chronic respiratory diseases. Finally, I will talk about my groups efforts in developing novel probes for detection of toxic compounds in our regional water sources.

3:50 Future Trends in POC Diagnostics

Sackrison_JimJim Sackrison, Consultant

This talk will discuss the future trends in POC diagnostics and where the field may be in the next 5, 10, 20 years.


4:20 End of Summit

* 주최측 사정에 따라 사전 예고없이 프로그램이 변경될 수 있습니다.