쇼트코스*

이 컨퍼런스의 쇼트코스는 강의와 양방향 토론의 조합으로 구성되어 있습니다. 클래스는 강사와 수강자가 1대1로 의견을 교환할 수 있는 정도의 규모이며 시간 또한 Q&A를 포함한 길이로 설정되어 있습니다. 내용은 경험이 적은 수강자를 고려한 기본적인 것과 메인 컨퍼런스의 연구 발표에서 시간적으로 다루기 어려운 기술적 측면의 심층 해설 등 다양합니다. 강사는 제약회사 및 대학에 소속되어 있으며 각 분야의 최고 전문가로서 인정받고 있거나 교원 경험이 있는 분들입니다.

4월 8일(월) 10:00 am – 1:00 pm

쇼트코스 1:공유결합 프래그먼트:표적 기반 스크리닝 및 표현형 스크리닝에 대한 응용

Topics include: design principles of covalent fragment libraries; target-based and phenotypic screens using covalent fragments; strategies to grow fragments into drug leads; case studies of coupling covalent fragment growth with selectivity profiling in cells.
Instructor:
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

쇼트코스 2:의약품의 물리적 특성 동향

Topics include: Properties that impact drug efficacy, development, delivery and formulation; including pKa, tautomerism, crystal structure interpretation among others. Use of computational tools.
Instructors:
Terry Stouch, PhD, President, R&D, Science for Solutions, LLC
Robert Fraczkiewicz, PhD, Team Leader, Simulations Plus, Inc.
Max Totrov, PhD, Principal Scientist, MolSoft, LLC

쇼트코스 3:GPCR 기반 Drug Discovery 입문

Topics include: GPCR pharmacology, including allosteric modulation; biased signaling, persistent signaling, and accessory proteins; emerging GPCR screening methods, including cellular redistribution assays; affinity mass spectrometry and biosensors.
Instructor:
Annette Gilchrist, PhD, Professor, Department of Pharmacology, Midwestern University

4월 8일(월) 2:00 – 5:00 pm

쇼트코스 5:리간드 수용체 분자간 상호작용과 약제 설계

Topics include: medicinal chemistry drug design principles illustrated via case studies such as interpretation of atomic-level protein X-ray and modeled structures of binding model; understanding the relative amounts of potency gain from different interactions; and case studies to illustrate all the design strategies.
Instructor:
Maricel Torrent, PhD, Senior Scientist III, Molecular Modeling, AbbVie

쇼트코스 5:리간드 수용체 분자간 상호작용과 약제 설계

Topics include: drug metabolism; CYP regulation; the role of bioactivation and how each affects lead optimization; and common assays and methodologies for predicting clearance and drug-drug interactions.
Instructors:
Zhengyin Yan, PhD, Principal Scientist, Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.
Donglu Zhang, PhD, Principal Scientist, Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.

쇼트코스 7:암 면역치료용 새로운 표적

Topics include: recently published data on immunology (STING, RIG- 1), epigenetic (HDAC, HAT), ubiquitin (DUBs, ligases) and autophagy targets; resulting strategies for development of new standalone or combination therapies for many types of cancers.
Instructors:
Wayne W. Hancock, MD, PhD, Professor of Pathology and Chief of Transplant Immunology, Children's Hospital of Philadelphia and University of Pennsylvania
Aditya Murthy, PhD, Scientist, Cancer Immunology, Genentech, Inc.
Additional Instructors to be Announced

4월 8일(월) 6:00 – 9:00 pm

쇼트코스 9:프래그먼트 기반 설계용 수단과 기술의 진보

Topics include: pros and cons of fragment-based approaches; what makes a good fragment; properties of a good fragment library; finding, validating and characterizing low affinity ligands; the importance of using orthogonal screening methods; and what to do with a fragment – growing, linking, and more.
Instructors:
Daniel A. Erlanson, PhD, Co-Founder, Carmot Therapeutics, Inc.
Ben Davis, PhD, Research Fellow, Biology, Vernalis Research

쇼트코스 10:리간드 발견을 위한 다양성 지향 플랫폼

Topics include: introduction to and comparison of these affinity-based drug discovery screening platforms: phage display, mRNA display and DNA-encoded libraries.
Instructor:
Svetlana Belyanskaya, PhD, Encoded Library Technologies, R&D Platform Technology & Science, GSK Boston
Additional instructor to be Announced

쇼트코스 11:PROTAC과 분자 접착제를 이용한 표적 단백질 분해

Topics include: basic understanding of proteolysis-targeting chimeric molecules (PROTACs); applying PROTACS to target and degrade specific proteins of interest; case studies from instructors’ research.
Instructors:
Lara Gechijian, PhD, Scientist/Project Lead, Jnana Therapeutics; Former Graduate Student, Laboratory of Drs. James Bradner/Nathanael Gray, Harvard Medical School
Eric Fischer, PhD, Assistant Professor, Cancer Biology, Dana-Farber Cancer Institute/Harvard Medical School
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

4월 10일(수) 6:30 – 9:00 pm

쇼트코스 13:유비퀴틴 프로테아좀계의 생화학과 약리학

Topics include: basic mechanistic biochemistry and pharmacology of the ubiquitin proteasome system, including E1, E2, E3, and deubiquitinating enzymes; signaling pathways regulated by UPS; the effect of small molecules on UPS-regulated pathways; assays and technologies for discovering enzyme inhibitors of the UPS system.
Instructor:
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

쇼트코스 14:화학 연구자를 위한 면역학 기초 강좌

Topics include: review of the immune system’s cellular players; review of the inflammatory process; autoimmune and inflammation-related diseases; current treatment landscape; promising drug targets; and principles in immuno-oncology (e.g., checkpoint blockade).
Instructors:
Songqing Na, PhD, Senior Scientist, Biotechnology & Autoimmunity Res-AME, Eli Lilly and Company
Additional Instructor to be Announced

쇼트코스 15:Drug Discovery를 위한 대환식 화합물의 연구:가능성, 문제, 전략

Topics include: unique characteristics of macrocycles; factors affecting cell permeability and PK/ADME properties; synthetic strategies for macrocyclic compound libraries and macrocyclization challenges; and drug discovery and development examples.
Instructors:
Eric Marsault, PhD, Professor, Medicinal Chemistry and Pharmacology, University of Sherbrooke
Mark Peterson, PhD, COO, Cyclenium Pharma, Inc.

쇼트코스 16:GPCR 구조 기반 Drug Discovery

Topics include: methodologies for the characterization and crystallization of GPCRs; a review of X-ray crystallographic and cryoEM GPCR structures and their lessons; biophysical tools (NMR, fluorescence spectroscopy, EPR, SPR and computational approaches) for observing function-related conformational dynamics of GPCRs; implications of structural knowledge on drug discovery especially related to allosteric modulation by small molecules, ions, and engineered partner proteins.
Instructors:
Matthew Eddy, PhD, Assistant Professor, Chemistry, University of Florida
Additional Instructor to be Announced


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