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단세포 시퀀싱 컨퍼런스 - 첫째날



최근 10년간 NGS 기술이 급속히 진보하고 비용도 큰폭으로 하락하면서 게놈 시퀀싱은 보다 일상화되고 있습니다. 이전에는 상상도 할 수 없었던 일이 지금은 가능합니다. 그러나 게놈 시퀀싱에서 사용되는 DNA의 다수는 다중 세포로부터 추출된 것으로, 유전자 발현, 세포 행동, 약물 반응 제어에 중대한 영향을 미칠 수도 있는 세포별 차이를 간과할 가능성도 있습니다. 한편, 단세포 시퀀싱에도 세포 격리, DNA 증폭, 바이오인포매틱스 등에 관련된 문제가 있습니다. 또한 시퀀싱 기술이 개선되면 미세한 게놈 재배열 등 세포간 약간의 차이가 표면화할 가능성도 있습니다. 이 컨퍼런스에서는 조직내 세포 변화와 장기 기능의 관련성, 질병 원인의 구명에 초점을 맞춥니다. 

첫째날 | 둘째날 

8월 20일(화)

12:00 pm Main Conference Registration

12:30 Luncheon Technology Workshop (Sponsorship Opportunity Available)

 

»Plenary Keynote Session

2:00 Chairperson's Opening Remarks

2:15 RNA is Everywhere: Characterizing the Spectra and Flux of RNA in Mammalian Circulation

David Galas, Ph.D., Principal Scientist, Pacific Northwest Diabetes Research Institute

The discovery of foreign RNA in blood and tissues of humans and mice raises many questions, including its origins, the mechanisms of its transport and stability and what, if any, functions it has. I will discuss what we know about circulating exRNA in human plasma and the use of NGS in the exploration of this new area of investigation in biology and medicine.

3:00 Genomics and the Single Cell

Sherman Weissman, Ph.D., Sterling Professor of Genetics and Medicine, Yale University School of Medicine

Studies of single cells are being approached by widely different methods, principally either florescence microscopy including super-high resolution methods, cloning and expansion of single cells or most generally applicable, genomic-scale nucleic acid analyses. The last includes single-cell DNA sequence analysis, gene expression analysis and most recently analyses of telomere length, DNA methylation and potentially closed regions of chromatin. Also, in the near future, it may be possible to combine several analyses of a single cell, including mRNA expression, genomic DNA methylation and protein secretion. These approaches will have major value for diverse fields, including molecular analysis of the early stages of development, the nature and heterogeneity of stem cells and transient repopulating cells in various systems including the hematopoietic system, the nature and extent of heterogeneity of neurons, heterogeneity in neoplasia and in functional subsets of cells of the immune system. A substantial experimental challenge is to distinguish technical variation from stochastic and deterministic events in single cells. Another, broader challenge is to correlate the results of genomic properties that necessarily involve destruction of the cell with the functional properties and potential of the individual cell being analyzed. These issues will be discussed briefly in the presentation.

3:45 Refreshment Break in the Exhibit Hall with Poster Viewing

4:30 Genome Hacking

Yaniv Erlich, Ph.D., Principal Investigator, Whitehead Fellow, Whitehead Institute for Biomedical Research

Sharing sequencing datasets without identifiers has become a common practice in genomics. We developed a technique that uses entirely free, publicly accessible Internet resources to fully identify individuals in these studies. I will present quantitative analysis about the probability of identifying U.S. individuals by this technique. In addition, I will demonstrate the power of our approach by tracing back the identities of multiple whole-genome datasets in public sequencing repositories.

5:15 Panel Discussion with Plenary Keynote Speakers

5:45 Short Course Registration

6:00-9:00 Dinner Short Courses (see page 2 for details) 

SC3: Assembly and Alignment
SC4: Cancer Genetics and Epigenetics 

 



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